Cyamemazine

Base Information

• Chemical Name: Cyamemazine
• CAS No.: 3546-03-0
• Molecular Formula: C19H21N3S
• Molecular Weight: 323.462
• Hs Code.: 2934300000
• European Community (EC) Number: 222-594-2
• UNII: A2JGV5CNU4
• DSSTox Substance ID: DTXSID80863190
• Nikkaji Number: J7.962F
• Wikipedia: Cyamemazine
• Wikidata: Q3008033
• NCI Thesaurus Code: C79120
• Pharos Ligand ID: HTPZUGGAC5JT
• Metabolomics Workbench ID: 152074
• ChEMBL ID: CHEMBL2104153
• Mol file: 3546-03-0.mol

Synonyms:10-(3-dimethylamino-2-methylpropyl)phenothiazine-2-carbonitrile;cyamamazine;cyamemazine;cyamemazine monohydrochloride;cyamepromazine

Chemical Property of Cyamemazine

Chemical Property:

• Vapor Pressure: 2.46E-09mmHg at 25°C
• Melting Point: 90-95°C
• Refractive Index: 1.654
• Boiling Point: 479 °C at 760 mmHg
• PKA: 9.31±0.28(Predicted)
• Flash Point: 243.5 °C
• PSA: 55.57000
• Density: 1.21 g/cm³
• LogP: 4.42368
• Storage Temp.: Refrigerator
• Solubility.: DMSO: ≥5mg/mL
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 323.14561886
• Heavy Atom Count: 23
• Complexity: 443

Purity/Quality:

99.9% ^*data from raw suppliers

Cyamemazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,N
• Hazard Codes: Xi,N
• Statements: 50
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CN1C2=CC=CC=C2SC3=C1C=C(C=C3)C#N)CN(C)C
• Uses: Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.
• Therapeutic Function: Tranquilizer

Technology Process of Cyamemazine

There total 17 articles about Cyamemazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

cyamemazine N-oxide (1366180-94-0) → N-Demethylcyamemazine (108014-19-3) + cyamemazine (3546-03-0)

Guidance literature:

With ferrous(II) sulfate heptahydrate; In methanol; at 0 ℃; for 2h;

DOI:10.1016/j.bmcl.2012.01.131

Reference yield:

3-(dimethylamino)-2-methylpropylchloride (23349-86-2) → cyamemazine (3546-03-0)

Guidance literature:

With sodium hydroxide; In toluene;

Reference yield:

Cyamemazine tartrate → cyamemazine (3546-03-0)

Guidance literature:

In [⁽²⁾H₆]acetone; water; ethyl acetate;

upstream raw materials:

10H-phenothiazine-2-carbonitrile

3-(dimethylamino)-2-methylpropylchloride

2-chlorophenothiazine

10H-phenothiazine-2-carboxylic acid

Refernces

• 1、 Bolla, R. Sekhar,Kasi Viswanath. "Synthesis of deuterium-labeled cyamemazine and monodesmethyl cyamemazine". . p. 82 - 85. Retrieved 2014/03/21.