4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

Base Information

Chemical Name:4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester
CAS No.:118537-48-7
Molecular Formula:C₂₁H₃₀O₄
Molecular Weight:346.467
Hs Code.:

Synonyms:4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

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Chemical Property of 4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

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Technology Process of 4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

There total 7 articles about 4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13756-42-8
tert-butyl 4-methylbenzoate

: 118537-48-7
4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / Heating

2: 72 percent / toluene / 18 h / 110 °C

3: 1) NaOMe / 1) DMSO, r.t., 15 min, 2) r.t., 18 h

4: 1) Davison sponge Ni, 2) H₂ / 2) 5percent Pd-C / 1) EtOAc, 2) 50 psi, 16 h

With N-Bromosuccinimide; Davison sponge Ni; hydrogen; sodium methylate; dibenzoyl peroxide; palladium on activated charcoal; In tetrachloromethane; toluene;
DOI:10.1021/jm00123a037

Reference yield:

: 108052-76-2
4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester

: 118537-48-7
4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / toluene / 18 h / 110 °C

2: 1) NaOMe / 1) DMSO, r.t., 15 min, 2) r.t., 18 h

3: 1) Davison sponge Ni, 2) H₂ / 2) 5percent Pd-C / 1) EtOAc, 2) 50 psi, 16 h

With Davison sponge Ni; hydrogen; sodium methylate; palladium on activated charcoal; In toluene;
DOI:10.1021/jm00123a037

Reference yield:

: 874-60-2
4-methyl-benzoyl chloride

: 118537-48-7
4-[2-(1,4-Dioxa-spiro[4.5]dec-8-yl)-ethyl]-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / pyridine / 72 h / Ambient temperature

2: 92 percent / N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / Heating

3: 72 percent / toluene / 18 h / 110 °C

4: 1) NaOMe / 1) DMSO, r.t., 15 min, 2) r.t., 18 h

5: 1) Davison sponge Ni, 2) H₂ / 2) 5percent Pd-C / 1) EtOAc, 2) 50 psi, 16 h

With pyridine; N-Bromosuccinimide; Davison sponge Ni; hydrogen; sodium methylate; dibenzoyl peroxide; palladium on activated charcoal; In tetrachloromethane; toluene;
DOI:10.1021/jm00123a037