tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate

Base Information

• Chemical Name: tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate
• CAS No.: 828932-23-6
• Molecular Formula: C₂₁H₂₀ClN₃O₄
• Molecular Weight: 413.861
• Mol file: 828932-23-6.mol

Synonyms:tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate

Chemical Property of tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate

There total 2 articles about tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-phenyl-1H-pyrrole-2,5-dione (4840-61-3) + (5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester (304873-96-9) → tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate (828932-23-6)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 3.5h;

Reference yield:

3-hydroxy-4-phenyl-1H-pyrrole-2,5-dione (84863-93-4) → tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate (828932-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / Heating / reflux

2: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3.5 h / 0 °C

With oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In DMF (N,N-dimethyl-formamide); dichloromethane;

Reference yield: 42.0%

tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate (828932-23-6) + 4-morpholino-4-yl-phenylamine (2524-67-6,86759-37-7) → 1-[(6-aminopyridine-3-yl)methyl]-3-[(4-morpholin-4-ylphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione (828932-18-9)

Guidance literature:

In DMF (N,N-dimethyl-formamide); at 150 ℃; for 0.166667h; Microwave irradiation;

upstream raw materials:

3-chloro-4-phenyl-1H-pyrrole-2,5-dione

(5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester

3-hydroxy-4-phenyl-1H-pyrrole-2,5-dione

Downstream raw materials:

1-[(6-aminopyridine-3-yl)methyl]-3-[(4-morpholin-4-ylphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione