84863-93-4

Upstream product

• 41339-39-3 4-Oxo-3-phenyl-1-oxa-5-aza-spiro[5.5]undec-2-ene-2-carboxylic acid ethyl ester 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 553-90-2 Dimethyl oxalate 
• 103-81-1 Benzeneacetamide 
• 95-92-1 oxalic acid diethyl ester 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 
• 64-17-5 ethanol 
• 7664-93-9 sulfuric acid 
• 6362-63-6 ethyl 3-cyano-3-phenylpyruvate 

Downstream Products

• 264206-68-0 3-[(4-methoxyphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione 
• 828932-07-6 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(2,2,2-trifluoroethyl)-1H-pyrrole-2,5-dione 
• 828932-16-7 1-[(6-aminopyridin-3-yl)methyl]-3-{[4-(difluoromethoxy)phenyl]amino}-4-phenyl-1H-pyrrole-2,5-dione 
• 828932-18-9 1-[(6-aminopyridine-3-yl)methyl]-3-[(4-morpholin-4-ylphenyl)amino]-4-phenyl-1H-pyrrole-2,5-dione 
• 828931-91-5 3-[(4-methoxyphenyl)amino]-4-phenyl-1-(pyridin-4-ylmethyl)-1H-pyrrole-2,5-dione 
• 828932-23-6 tert-butyl {5-[(3-chloro-2,5-dioxo-4-phenyl-2,5-dihydro-1H-pyrrol-1-yl)methyl]pyridin-2-yl}carbamate 
• 1567434-97-2 C₂₃H₁₉FN₄O₃ 
• 4840-61-3 3-chloro-4-phenyl-1H-pyrrole-2,5-dione 

Relevant academic research and scientific papers

Synthesis of aryl anilinomaleimide based derivatives as glycogen synthase kinase-3β inhibitors with potential role as antidepressant agents

A series of aryl anilinomaleimide based derivatives has been synthesized and evaluated for in vitro glycogen synthase kinase-3β (GSK-3β) inhibitory activity. A large number of compounds from the series exhibited moderate to potent inhibitory activity against GSK-3β, with more than one-third of the compounds showing inhibition with IC50 values 50 values of 0.09, 0.12, 0.17, 0.19, 0.21 and 0.23 μM respectively), were further investigated for antidepressant activity by the widely accepted forced swim test and tail suspension test (FST and TST) models. All the tested compounds displayed antidepressant-like effects, particularly compounds 8j and 8b, which exhibited significant antidepressant activity, about 1.4-fold higher than fluoxetine, a standard antidepressant drug in both FST and TST. Preliminary structure-activity relationships have also been generated based on the experimental data obtained.

Anilino-monoindolylmaleimides as potent and selective JAK3 inhibitors

We designed a series of anilino-indoylmaleimides based on structural elements from literature JAK3 inhibitors 3 and 4, and our lead 5. These new compounds were tested as inhibitors of JAKs 1, 2 and 3 and TYK2 for therapeutic intervention in rheumatoid art

Synthesis, cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimides

A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in-vitro cytotoxicity against various human cancer cell lines and their protein-kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity

5-THIOXO-1,5-DIHYDRO-2H-PYRROL-2-ONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS

The present invention relates to certain novel compounds of the Formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating clinic

PLANT GROWTH REGULATION

The present invention relates to the use of a compound for plant growth regulation, preferably by application of the compound to plants, to the seeds from which they grow or to the locus in which they grow, in an effective plant growth regulating, prefera

PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS

The present invention relates to certain novel compounds of the Formula I to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating clinical

PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS

The present invention relates to certain novel compounds of the Formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) α (NR1H3) and/or β (NR1H2) and in treating and/or

3-Anilino-4-arylmaleimides: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases.

Rearrangement of 1-Oxa-5-azabicyclo[5.5]undec-2-en-4-ones to 5,6,7,8- Tetrahydroquinolin-2(1H)-ones

Spiro compounds 1 are easily converted into tetrahydroquinolin-2-ones 2 in a one step reaction involving anhydrous strong acidic conditions. A plausible mechanism is discussed.