Technology Process of 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-1-benzopyran-3-carboxamide
There total 12 articles about 7-[(methylsulfonyl)amino]-4-oxo-6-phenoxy-4H-1-benzopyran-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
ammonia; trichlorophosphate;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 72 percent / 4N aq. HCl; Fe / ethanol / 0.33 h / 65 - 70 °C
2: 82 percent / pyridine / 1 h / 20 °C
3: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
4: 50 percent / NaH / dimethylformamide
5: 66 percent / NaH / dimethylformamide / 0.5 h / 90 - 100 °C
6: 90 percent / H2 / 5 percent Pd/C / ethanol
7: 89 percent / dimethylformamide / 1 h / 20 °C
8: 91 percent / 6N aq. HCl / dioxane / 0.5 h / Heating
9: POCl3 / dimethylformamide / 3 h / -10 - -5 °C
10: 25 percent aq. NH4OH / 0.5 h / 10 - 20 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; aluminium trichloride; hydrogen; iron; sodium hydride; trichlorophosphate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
1: Reduction / 2: Mesylation / 3: Acetylation / 4: Alkylation / 5: ethoxycarbonylation / 6: catalytic hydrogenolysis / 7: Cyclization / 8: Hydrolysis / 9: Chlorination / 10: amidation;
DOI:10.1248/cpb.48.131
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 82 percent / pyridine / 1 h / 20 °C
2: 84 percent / aluminum chloride / CH2Cl2 / 1 h / 15 - 20 °C
3: 50 percent / NaH / dimethylformamide
4: 66 percent / NaH / dimethylformamide / 0.5 h / 90 - 100 °C
5: 90 percent / H2 / 5 percent Pd/C / ethanol
6: 89 percent / dimethylformamide / 1 h / 20 °C
7: 91 percent / 6N aq. HCl / dioxane / 0.5 h / Heating
8: POCl3 / dimethylformamide / 3 h / -10 - -5 °C
9: 25 percent aq. NH4OH / 0.5 h / 10 - 20 °C
With
pyridine; hydrogenchloride; ammonium hydroxide; aluminium trichloride; hydrogen; sodium hydride; trichlorophosphate;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;
1: Mesylation / 2: Acetylation / 3: Alkylation / 4: ethoxycarbonylation / 5: catalytic hydrogenolysis / 6: Cyclization / 7: Hydrolysis / 8: Chlorination / 9: amidation;
DOI:10.1248/cpb.48.131
