Technology Process of 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylic acid
There total 7 articles about 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate;
With
methanol; water; lithium hydroxide;
In
tetrahydrofuran;
at 20 - 25 ℃;
for 3h;
With
hydrogenchloride; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux
2.1: bromine / chloroform / 1 h / 0 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C
4.1: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / 1,2-dimethoxyethane / 100 °C
5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 - 20 °C
5.2: 1 h / 0 °C
6.1: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); sulfuryl dichloride; lithium hydroxide monohydrate; water; bromine; sodium hydride; potassium carbonate; cesium fluoride;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide; paraffin oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: bromine / chloroform / 1 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C
3.1: tetrakis(triphenylphosphine) palladium(0); cesium fluoride / 1,2-dimethoxyethane / 100 °C
4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 - 20 °C
4.2: 1 h / 0 °C
5.1: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 3 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); lithium hydroxide monohydrate; water; bromine; sodium hydride; potassium carbonate; cesium fluoride;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; paraffin oil;
