ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

Base Information

Chemical Name:ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate
CAS No.:1168134-15-3
Molecular Formula:C₂₂H₁₉ClF₆O₃
Molecular Weight:480.834
Hs Code.:

Synonyms:ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

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Chemical Property of ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

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Technology Process of ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

There total 6 articles about ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1168135-02-1
ethyl 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4’-(trifluoromethyl)biphenyl-3-yl)acetate

: 109-64-8
1,3-dibromo-propane

: 1168134-15-3
ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

Guidance literature:: ethyl 2-(5-chloro-6-(2,2,2-trifluoroethoxy)-4’-(trifluoromethyl)biphenyl-3-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 25 ℃;

1,3-dibromo-propane; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 17138-28-2
(4-hydroxy-phenyl)-acetic acid ethyl ester

: 1168134-15-3
ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / methanol; dichloromethane / 5 h / Reflux

2.1: bromine / chloroform / 1 h / 0 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 100 °C

5.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 - 20 °C

5.2: 1 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuryl dichloride; bromine; sodium hydride; potassium carbonate; cesium fluoride; In methanol; 1,2-dimethoxyethane; dichloromethane; chloroform; N,N-dimethyl-formamide; paraffin oil;

Reference yield:

: 193357-36-7
3-chloro-4-hydroxyphenylacetic acid ethyl ester

: 1168134-15-3
ethyl 1-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)cyclobutane carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / chloroform / 1 h / 0 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / 1,2-dimethoxyethane / 100 °C

4.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.5 h / 0 - 20 °C

4.2: 1 h / 0 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium hydride; potassium carbonate; cesium fluoride; In 1,2-dimethoxyethane; chloroform; N,N-dimethyl-formamide; paraffin oil;