85148-33-0

Upstream product

• 91401-72-8 2-(ω-phenyl-propionyl)-phenoxy-acetic acid 
• 3516-95-8 2'-hydroxy-3-phenylpropiophenone 
• 36638-16-1 2,3-dihydro-3-methylenebenzofuran 
• 157493-96-4 2-(2-(3-phenylpropionyl)-phenoxy)-essigsaeureethylester 
• 165279-81-2 2-Chlor-1-(2,3-dihydro-3-hydroxy-3-(2-phenylethyl)benzofuran-2-yl)ethanon 
• 64-17-5 ethanol 

Downstream Products

• 158358-16-8 1-(3-phenylethylbenzofuran-2-yl)ethan-1-one 
• 146366-93-0 3-(2-phenylethyl)-α-(2-tetrahydropyranyloxy)-2-benzofuranacetonitrile 
• 146396-22-7 3-(2-phenylethyl)-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine 
• 157494-00-3 α-(tert-butyldimethylsilyloxy)-3-(2-phenylethyl)-2-benzofuranacetonitrile 
• 157493-97-5 α-hydroxy-3-(2-phenylethyl)-2-benzofuranacetonitrile 
• 183883-07-0 2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-[3-(2-phenylethyl)-2-benzofuryl]ethanone 
• 146366-94-1 3-(2-phenylethyl)-N-propyl-β-(2-tetrahydropyranyloxy)-2-benzofuranethanamine 
• 158358-22-6 (S)-(-)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol 
• 158358-22-6 (R)-(+)-1-(3-phenethylbenzofuran-2-yl)-2-propylaminoethanol 
• 146366-92-9 3-(2-phenylethyl)-2-benzofurancarbaldehyde 

Relevant academic research and scientific papers

Copper-catalyzed oxidative heck reactions between alkyltrifluoroborates and vinyl arenes

We report herein that potassium alkyltrifluoroborates can be utilized in oxidative Heck-type reactions with vinyl arenes. The reaction is catalyzed by a Cu(OTf)2/1,10-phenanthroline with MnO2 as the stoichiometric oxidant. In addition to the alkyl Heck, amination, esterification, and dimerization reactions of alkyltrifluoroborates are demonstrated under analogous reaction conditions. Evidence for an alkyl radical intermediate is presented.

Synthesis and pharmacodynamic activity of 2-(3-(2-phenylethyl)benzofuran-2-yl)-N-propyl-ethanamine

The benzofuranethanamines 3a and 3b were synthesized and pharmacologically tested to investigate structure-activity relationships with antiarrhythmic compounds. The key-step in the synthesis was the chemoselective reduction of the chloroacetyl-dihydrobenzofurane 5 to chloroethylbenzofurane 9 using triethylsilane/BF3.Et2O. Results of a series of further attempts to reduce 5 are also described. Pharmacological investigations on isolated guinea pig heart muscle preparations showed that 3a exhibits similar negative inotropic and negative chronotropic action in comparison to propafenone and the conformationally restricted benzofurane 1a. In contrast to these substances, however, 3a shows no beta 1-adrenoreceptor blocking activity.

New Benzofuran-Type Antiarrhythmic Compounds Related to Propafenone

Synthesis of two benzofuran compounds (2a and 2b), which are structurally and - by their action as sodium channel blockers - also pharmacologically related to propafenone is described.