2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid

Base Information

Chemical Name:2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid
CAS No.:1244018-43-6
Molecular Formula:C₂₆H₂₄N₂O₄
Molecular Weight:428.488
Hs Code.:

Synonyms:2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid

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Chemical Property of 2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid

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Technology Process of 2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid

There total 1 articles about 2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15855-06-8
2-chloro-6-methoxy-isonicotinic acid

: 1244016-75-8
4-(4-((4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethynyl)benzyl)morpholine

: 1244018-43-6
2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid

Guidance literature:: 2-chloro-6-methoxy-isonicotinic acid; 4-(4-((4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)ethynyl)benzyl)morpholine; With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 100 ℃; for 1h; Inert atmosphere; microwave irradiation;

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate; pH=1;

Reference yield:

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1244018-43-6
2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)isonicotinic acid

: 1244018-44-7
2-methoxy-6-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)-N-(tetrahydro-2H-pyran-2-yloxy)isonicotinamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;