6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Name:6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide
CAS No.:1380656-63-2
Molecular Formula:C₃₁H₂₆FN₅O₅
Molecular Weight:567.576
Hs Code.:

Synonyms:6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

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Chemical Property of 6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

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Technology Process of 6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

There total 10 articles about 6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

: 1380656-62-1
2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)oxetan-3-yl)carbamoyl)phenyl)-N-methyl-6-nitrobenzofuran-3-carboxamide

: 1380656-63-2
6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: With indium; ammonium chloride; In ethanol; at 90 ℃; Inert atmosphere; Sealed tube;

Reference yield:

: 89-55-4
5-bromosalicyclic acid

: 1380656-63-2
6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetone / 50 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 3 h / 100 °C / Microwave irradiation

3: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

4: sodium hydroxide; water / tetrahydrofuran / 50 °C

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

6: indium; ammonium chloride / ethanol / 90 °C / Inert atmosphere; Sealed tube

With indium; water; potassium acetate; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; caesium carbonate; triethylamine; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 478375-37-0
methyl 2-methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoate

: 1380656-63-2
6-amino-2-(4-fluorophenyl)-5-(4-methoxy-3-((3-(pyrimidin-2-yl)-oxetan-3-yl)carbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 50 °C

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: indium; ammonium chloride / ethanol / 90 °C / Inert atmosphere; Sealed tube

With indium; water; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; caesium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;