5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Base Information

Chemical Name:5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide
CAS No.:1354786-50-7
Molecular Formula:C₂₄H₁₃Cl₂F₂N₅O₃S₂
Molecular Weight:592.434
Hs Code.:

Synonyms:5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Suppliers and Price of 5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

There total 8 articles about 5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1354787-27-1
5-chloro-4-(6-chloro-2'-fluoro-4-(pyridazin-4-yl)biphenyl-3-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354786-50-7
5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 18h;

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1354786-50-7
5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

2: sulfuric acid; acetic acid; N-iodo-succinimide / dichloromethane / 18 h / 20 °C

3: boron tribromide / dichloromethane / 18 h / -20 - 20 °C

4: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

5: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 45 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; copper(l) iodide; sulfuric acid; boron tribromide; potassium carbonate; caesium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki Coupling / 5: Stille Coupling;

Reference yield:

: 2732-80-1
2-bromo-1-chloro-4-methoxybenzene

: 1354786-50-7
5-Chloro-4-[(6-chloro-2'-fluoro-4-pyridazin-4-ylbiphenyl-3-yl)oxy]-2-fluoro-N-1,3,4-thiadiazol-2-ylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 80 °C / Inert atmosphere

2: sulfuric acid; acetic acid; N-iodo-succinimide / dichloromethane / 18 h / 20 °C

3: boron tribromide / dichloromethane / 18 h / -20 - 20 °C

4: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

5: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 45 °C / Inert atmosphere

6: hydrogenchloride / 1,4-dioxane / 18 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; copper(l) iodide; sulfuric acid; boron tribromide; potassium carbonate; caesium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki Coupling / 5: Stille Coupling;