3-BROMO-4-CHLOROANISOLE

Base Information

• Chemical Name: 3-BROMO-4-CHLOROANISOLE
• CAS No.: 2732-80-1
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.481
• Hs Code.: 2909309090
• Mol file: 2732-80-1.mol

Synonyms:Anisole,3-bromo-4-chloro- (7CI,8CI);1-Bromo-2-chloro-5-methoxybenzene;2-Bromo-1-chloro-4-methoxybenzene;

Chemical Property of 3-BROMO-4-CHLOROANISOLE

Chemical Property:

• Vapor Pressure: 0.0477mmHg at 25°C
• Melting Point: 179-180℃
• Refractive Index: 1.556
• Boiling Point: 231.9 °C at 760 mmHg
• Flash Point: 94.1 °C
• PSA: 9.23000
• Density: 1.564 g/cm³
• LogP: 3.11110
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-4-chloroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-51

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-4-chloroanisole is a useful synthetic intermediate. It can be used in the synthesis of N-heterocycle-fused phenanthridines as blue-emitting luminophores. It can also be used to prepare indoles (Indole, I577320) by a Pd-Catalyzed Cascade process.

Technology Process of 3-BROMO-4-CHLOROANISOLE

There total 7 articles about 3-BROMO-4-CHLOROANISOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-5-methoxyaniline (2401-24-3) → 2-bromo-1-chloro-4-methoxybenzene (2732-80-1)

Guidance literature:

2-chloro-5-methoxyaniline; With hydrogen bromide; sodium nitrite; In water; acetonitrile; at 20 ℃; for 0.5h;

With copper(I) bromide; In water; acetonitrile; at 60 ℃;

DOI:10.1002/chem.201701707

Reference yield: 84.0%

3-bromo-4-chlorophenol (13659-24-0) + methyl iodide (74-88-4) → 2-bromo-1-chloro-4-methoxybenzene (2732-80-1)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 40 ℃; for 16h;

Reference yield:

2-chloro-5-methoxynitrobenzene (10298-80-3) → 2-bromo-1-chloro-4-methoxybenzene (2732-80-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SnCl₂; aqueous HCl

2: sodium nitrite; aqueous hydrobromic acid / anschliessendes Erwaermen mit Kupfer(I)-bromid

With hydrogenchloride; hydrogen bromide; tin(ll) chloride; sodium nitrite;

DOI:10.1021/ja01608a009

upstream raw materials:

2-chloro-5-methoxyaniline

3-bromo-4-chlorophenol

dimethyl sulfate

2,3,6-tribromo-4-chloro-phenol

Downstream raw materials:

1-chloro-2-(4-fluorophenoxy)-4-methoxybenzene

3-bromo-4-chlorophenol

(E)-5-methoxy-1-phenyl-2-styryl-1H-indole

2-chloro-N-(2,6-diisopropylphenyl)-5-methoxyaniline