2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride

Base Information

• Chemical Name: 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride
• CAS No.: 1245622-62-1
• Molecular Formula: C₁₀H₁₁F₃N₂O₂*ClH
• Molecular Weight: 284.666
• Mol file: 1245622-62-1.mol

Synonyms:2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride

Chemical Property of 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride

There total 1 articles about 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

isocyanate de chlorosulfonyle (1189-71-5) + tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate (1245622-61-0) → 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride (1245622-62-1)

Guidance literature:

isocyanate de chlorosulfonyle; tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate; In acetonitrile; at -15 ℃; for 0.166667h;

With water; In acetonitrile; at -15 - 60 ℃;

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.0833333h;

Reference yield: 83.0%

{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid (959140-61-5) + 2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride (1245622-62-1) → 2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[2-(trifluoromethyl)phenyl]ethyl carbamate (1245620-49-8)

Guidance literature:

{3-(4-chlorophenyl)-5-oxo-4-[(2,S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 0.166667h;

2-Amino-2-[2-(trifluoromethyl)phenyl]ethyl carbamate hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃;

upstream raw materials:

isocyanate de chlorosulfonyle

tert-Butyl {2-hydroxy-1-[2-(trifluoromethyl)phenyl]ethyl}carbamate

Downstream raw materials:

2-[({3-(4-Chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetyl)amino]-2-[2-(trifluoromethyl)phenyl]ethyl carbamate