(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

Base Information

Chemical Name:(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester
CAS No.:111433-90-0
Molecular Formula:C₃₂H₃₆Cl₃N₃O₆S
Molecular Weight:697.079
Hs Code.:

(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

Synonyms:(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

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Chemical Property of (1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

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Technology Process of (1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

There total 6 articles about (1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 127940-23-2,107454-63-7
N-2,2,2-trichloroethoxycarbonyl-L-prolinyl chloride

: 111427-92-0
(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

: 111433-90-0
(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85828-2

Reference yield:

: 64793-86-8
3-methyl-3-phenylsulfanyl-butanoic acid

: 111433-90-0
(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) Lawesson's reagent

2: 1.) MeI; 2.) NaBH₄

3: 92 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With Lawessons reagent; sodium tetrahydroborate; triethylamine; methyl iodide; In dichloromethane;
DOI:10.1016/S0040-4020(01)85828-2

Reference yield:

: 37888-34-9
<<(2,2,2-trichloroethyl)oxy>carbonyl>-L-proline

: 111433-90-0
(1S,3S)-7-Methoxy-1-(2-methyl-2-phenylsulfanyl-propyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / Ambient temperature

2: 92 percent / triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4020(01)85828-2