N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine

Base Information

• Chemical Name: N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine
• CAS No.: 128017-19-6
• Molecular Formula: C₁₉H₂₅NO₂
• Molecular Weight: 299.413
• Mol file: 128017-19-6.mol

Synonyms:N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine

Chemical Property of N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine

There total 5 articles about N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-Benzyl-2-(4-methoxy-phenyl)-3-methyl-[1,3]oxazinan-3-ium; iodide (128017-09-4) → N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine (128017-19-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 67 ℃; for 3h;

DOI:10.1055/s-1990-26819

Reference yield: 40.0%

3-Benzyl-2-(4-methoxy-phenyl)-3-methyl-[1,3]oxazinan-3-ium; iodide (128017-09-4) → N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine (128017-19-6)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 66h;

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → N-benzyl-N-methyl-3-(p-methoxy)benzyloxypropylamine (128017-19-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / p-TsOH / toluene / 3 h / 110 °C

2: 88 percent / 12 h / 20 °C

3: 78 percent / LiAlH₄ / diethyl ether / 3 h / 67 °C

With lithium aluminium tetrahydride; toluene-4-sulfonic acid; In diethyl ether; toluene;

DOI:10.1055/s-1990-26819

upstream raw materials:

3-Benzyl-2-(4-methoxy-phenyl)-3-methyl-[1,3]oxazinan-3-ium; iodide

3-Benzyl-2-(4-methoxy-phenyl)-[1,3]oxazinane

4-methoxy-benzaldehyde

3-(benzylamino)propan-1-ol