(R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

Base Information

Chemical Name:(R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile
CAS No.:247039-08-3
Molecular Formula:C₁₆H₁₅FN₂OS
Molecular Weight:302.372
Hs Code.:

(R<sub>S</sub>)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

Synonyms:(R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

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Chemical Property of (R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

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Technology Process of (R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

There total 5 articles about (R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 5804-85-3
diethylaluminium cyanide

: (R_S)-(-)-N-(2(R)-2-fluorophenylacetylidene)-p-toluenesulfinamide

: 247039-08-3
(R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

: 4-Methyl-benzenesulfinic acid ((1R,2R)-1-cyano-2-fluoro-2-phenyl-ethyl)-amide

Guidance literature:: With isopropyl alcohol; In tetrahydrofuran; at -78 - 20 ℃; for 12h;
DOI:10.1021/jo990947n

Reference yield:

: 643-77-6
fluoro-phenyl-acetic acid ethyl ester

: 247039-08-3
(R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAL-H

2: 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

3: 80 percent / i-PrOH / tetrahydrofuran / 12 h / -78 - 20 °C

With 4 A molecular sieve; diisobutylaluminium hydride; isopropyl alcohol; In tetrahydrofuran; dichloromethane; 1: Reduction / 2: Substitution / 3: Addition;
DOI:10.1021/jo990947n

Reference yield:

: 13344-76-8
α-fluorobenzeneacetaldehyde

: 247039-08-3
(R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 4 Angstroem molecular sieves / CH₂Cl₂ / 20 °C

2: 80 percent / i-PrOH / tetrahydrofuran / 12 h / -78 - 20 °C

With 4 A molecular sieve; isopropyl alcohol; In tetrahydrofuran; dichloromethane; 1: Substitution / 2: Addition;
DOI:10.1021/jo990947n