643-77-6

Basic information

• Product Name: Benzeneacetic acid, a-fluoro-, ethyl ester
• CAS NO: 643-77-6
• Molecular Formula: C10H11FO2
• Molecular Weight: 182.195
• Mol File: 643-77-6.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: Benzeneacetic acid, a-fluoro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetic acid, a-fluoro-, ethyl ester(643-77-6)
• EPA Substance Registry System: Benzeneacetic acid, a-fluoro-, ethyl ester(643-77-6)

Safety Data

• Hazardous Substances Data: 643-77-6(Hazardous Substances Data)

Upstream product

• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 31491-20-0 (1-ethoxy-2-phenylvinyloxy)trimethylsilane 
• 78935-61-2 (Z)-((1-ethoxy-2-phenylvinyl)oxy)trimethylsilane 
• 78935-57-6 trimethylsilyl ketene acetal of ethyl phenylacetate 
• 28744-77-6 sodium diethyl-2-phenylmalonate 
• 101-97-3 Ethyl 2-phenylethanoate 
• 64-17-5 ethanol 
• 1578-63-8 d'acide 2-fluoro-2-phenyl acetique 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 1117-96-0 Diazoethan 
• 19242-50-3 ethyl 3-hydroxy-2-phenylprop-2-enoate 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 83-13-6 diethyl 2-phenylmalonate 
• 373-91-1 hypofluorous acid trifluoromethyl ester 

Downstream Products

• 32154-48-6 4-Fluoro-2,2-dimethyl-3-oxo-4-phenyl-butyric acid ethyl ester 
• 13344-76-8 α-fluorobenzeneacetaldehyde 
• 1126-71-2 N,N-dimethylphenethylamine 
• 14204-06-9 α-fluoro-N,N-dimethylbenzeneacetamide 
• 14204-07-0 2-fluoro-2-phenylacetamide 
• 14204-09-2 N_.N-Dimethyl-2-fluor-2-phenyl-aethylamin 
• 63818-95-1 S(+)-acide fluoro-2 phenyl-2 acetique 
• 63818-94-0 (R)-α-fluoro-α-phenylacetic acid 
• 1578-78-5 α-fluoro-α-phenylmalonic acid 
• 247039-05-0 (R_S)-(+)-2-[N-(p-toluenesulfinamido)]-3-(S)-fluoro-3-phenylpropionitrile 
• 247039-08-3 (R_S)-(-)-2-[N-(p-toluenesulfinamido)]-3-(R)-fluoro-3-phenylpropionitrile 

Relevant articles and documents

Divergent Synthesis of α-Fluorinated Carbonyl and Carboxyl Derivatives by Double Electrophilic Activation of Amides

A straightforward and divergent entry to α-fluorinated carbonyl and carboxyl derivatives is reported. Upon activation of amides with triflic anhydride and a 2-halo-pyridine and subsequent trapping of the resulting keteniminium ions with nucleophiles followed by a second electrophilic activation with NFSI and final hydrolysis, a range of amides can be transformed to α-fluorinated ketones, esters, and amides under mild conditions. Moreover, this reaction can be performed to yield enantioenriched products with a traceless chiral auxiliary.

Organo-catalyzed Michael addition of 2-fluoro-2-arylacetonitriles

An efficient synthesis of a variety of 2-arylacetonitriles containing a fluorinated stereogenic center through organo-catalyzed Michael addition reaction of 2-fluoro-2-arylacetonitriles has been developed. This protocol uses a cheap organocatalyst (DBU) and has a broad substrate scope: α, β-unsaturated ketones, esters, nitriles and sulfones were all successfully reacted. Importantly, water proved to be a good solvent for this reaction.

AZABICYCLO AND DIAZEPINE DERIVATIVES FOR TREATING OCULAR DISORDERS

The present invention provides in one aspect azabicycio and diazepine derivatives useful as modulators of muscarinic receptors. In another aspect, the present invention provides pharmaceutical compositions for treating ocular diseases, the compositions comprising at least one muscarinic receptor modulator. Formulae (I) & (II):