4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

Base Information

Chemical Name:4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone
CAS No.:86073-62-3
Molecular Formula:C₂₂H₂₂ClNO₃
Molecular Weight:383.875
Hs Code.:
DSSTox Substance ID:DTXSID70235387
Nikkaji Number:J78.028F
Wikidata:Q83117279

Synonyms:4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone;BRN 6002067;86073-62-3;Flavone, 4'-chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)-;4H-1-Benzopyran-4-one, 2-(4-chlorophenyl)-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)-;C22H22ClNO3;DTXSID70235387;LS-68959

Suppliers and Price of 4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

Chemical Property:

Vapor Pressure:3.27E-11mmHg at 25°C
Boiling Point:527.4°C at 760 mmHg
Flash Point:272.8°C
Density:1.271g/cm³
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:383.1288213
Heavy Atom Count:27
Complexity:578

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(OC2=C(C1=O)C=CC(=C2CN3CCCC3)OC)C4=CC=C(C=C4)Cl

Technology Process of 4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

There total 4 articles about 4'-Chloro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 123-75-1
pyrrolidine

: 86073-67-8
3-Methyl-7-methoxy-8-chloromethyl-4'-chloroflavone

: 86073-62-3
3-Methyl-7-methoxy-8-pyrrolidinomethyl-4'-chloroflavone

Guidance literature:: In benzene; for 48h; Ambient temperature;
DOI:10.1002/ardp.19833160507

Reference yield:

: 6270-44-6
2-hydroxy-4-methoxypropiophenone

: 86073-62-3
3-Methyl-7-methoxy-8-pyrrolidinomethyl-4'-chloroflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / sodium p-chlorobenzoate / 8 h / 180 - 190 °C

2: 80 percent / HCl / acetic acid; aq. HCl / 5 h / 70 - 80 °C

3: 70 percent / benzene / 48 h / Ambient temperature

With hydrogenchloride; sodium p-chlorobenzoate; In hydrogenchloride; acetic acid; benzene;
DOI:10.1002/ardp.19833160507

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 86073-62-3
3-Methyl-7-methoxy-8-pyrrolidinomethyl-4'-chloroflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / sodium p-chlorobenzoate / 8 h / 180 - 190 °C

2: 80 percent / HCl / acetic acid; aq. HCl / 5 h / 70 - 80 °C

3: 70 percent / benzene / 48 h / Ambient temperature

With hydrogenchloride; sodium p-chlorobenzoate; In hydrogenchloride; acetic acid; benzene;
DOI:10.1002/ardp.19833160507