(+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

Base Information

Chemical Name:(+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide
CAS No.:500707-17-5
Molecular Formula:C₁₂H₁₆N₂O₃S
Molecular Weight:268.337
Hs Code.:

Synonyms:(+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

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Chemical Property of (+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

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Technology Process of (+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

There total 3 articles about (+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4229-44-1
N-methylhydroxyamine hydrochloride

: 500707-14-2
(E)-(+)-N-[(1S)-1-methyl-2-oxoethyl]-2-phenylethylenesulfonamide

: 500707-17-5
(+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

: (3R,3aS,6S,6aR)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

Guidance literature:: With triethylamine; In ethanol; for 24h; Heating;
DOI:10.1016/S0957-4166(02)00465-2

Reference yield:

: 52147-97-4
trans 2-phenylethenesulfonyl chloride

: 500707-17-5
(+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Et₃N / CH₂Cl₂ / 16.5 h / 0 - 25 °C

2: 85 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.5 h

3: 78 percent / Et₃N / ethanol / 24 h / Heating

With Dess-Martin periodane; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/S0957-4166(02)00465-2

Reference yield:

: 500707-11-9
(E)-(-)-N-[(1S)-2-hydroxy-1-methylethyl]-2-phenylethylenesulfonamide

: 500707-17-5
(+)-(3S,3aR,6S,6aS)-1,6-dimethyl-3-phenylhexahydroisothiazolo[4,5-c]isoxazole 4,4-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / Dess-Martin periodinane / CH₂Cl₂; H₂O / 0.5 h

2: 78 percent / Et₃N / ethanol / 24 h / Heating

With Dess-Martin periodane; triethylamine; In ethanol; dichloromethane; water;
DOI:10.1016/S0957-4166(02)00465-2