tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Base Information

• Chemical Name: tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate
• CAS No.: 174775-05-4
• Molecular Formula: C₁₇H₃₂N₂O₄
• Molecular Weight: 328.452
• Mol file: 174775-05-4.mol

Synonyms:tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Chemical Property of tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

There total 1 articles about tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-07-6) → tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-05-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 16h; Heating;

DOI:10.1248/cpb.47.1694

Reference yield: 37.0%

5-(benzyloxycarbonylamidino)-2-benzofurancarboxylic acid (174774-65-3) + tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-05-4) → [(4-{[5-(benzyloxycarbonylamino-imino-methyl)-benzofuran-2-carbonyl]-amino}-cyclohexyl)-tert-butoxycarbonyl-amino]-acetic acid tert-butyl ester (174775-08-7)

Guidance literature:

With benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1248/cpb.47.1694

Reference yield:

tert-butyl trans-[4-aminocyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174775-05-4) → tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate (174774-25-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / HOBt; EDI / dimethylformamide / 18 h / 20 °C

2: 86 percent / H₂ / 10 percent Pd/C / ethanol / 16 h / Heating

With hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; 1: coupling / 2: Hydrogenolysis;

DOI:10.1248/cpb.47.1694

upstream raw materials:

tert-butyl trans-[4-(triphenylmethylamino)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate

Downstream raw materials:

[(4-{[5-(benzyloxycarbonylamino-imino-methyl)-benzofuran-2-carbonyl]-amino}-cyclohexyl)-tert-butoxycarbonyl-amino]-acetic acid tert-butyl ester

tert-butyl trans-[4-(5-amidinobenzofuran-2-carboxamido)cyclohexyl-N-(tert-butoxycarbonyl)amino]acetate