tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate
CAS No.:1426071-36-4
Molecular Formula:C₁₉H₂₅F₂N₃O₄
Molecular Weight:397.422
Hs Code.:

Synonyms:tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

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Technology Process of tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

There total 5 articles about tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 314741-40-7
(3S)-3-(hydroxymethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

: 1426073-15-5
2,6-difluoro-3-(oxiran-2-yl)benzonitrile

: 1426071-36-4
tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: In ethanol; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 946796-26-5
2,6-difluoro-3-hydroxybenzonitrile

: 1426071-36-4
tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 4 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 0 - 20 °C

4: ethanol / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

Reference yield:

: 886498-35-7
2,6-difluoro-3-methoxy-benzonitrile

: 1426071-36-4
tert-butyl (3S)-4-[2-(3-cyano-2,4-difluorophenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 0 - 20 °C

2: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethanol / 4 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 0 - 20 °C

5: ethanol / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron tribromide; triethylamine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;