(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate

Base Information

• Chemical Name: (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate
• CAS No.: 1108146-41-3
• Molecular Formula: C₂₉H₂₉N₃O₆
• Molecular Weight: 515.566

Synonyms:(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate

Chemical Property of (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate

There total 5 articles about (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N-α-benzyloxycarbonyl-DL-tyrosine (5618-98-4) + (S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) → (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate (1108146-41-3)

Guidance literature:

With 4-methyl-morpholine; DMT*brucine tetrafluoroborate; brucine; In acetonitrile; at 0 - 20 ℃; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol802691x

Reference yield: 76.0%

(S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(tertbutoxy)phenyl)propanamido)-3-(1H-indol-3-yl)propanoate → (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate (1108146-41-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1039/c6cc09998j

Reference yield: 72.0%

Z-L-Tyr-OH (1164-16-5) + (S)-tryptophan methyl ester hydrochloride (7524-52-9,26988-71-6,5619-09-0,14907-27-8,41222-70-2,67557-19-1,109492-62-8) → (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate (1108146-41-3)

Guidance literature:

Z-L-Tyr-OH; (S)-tryptophan methyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; Inert atmosphere;

With benzotriazol-1-ol; 1,2-dichloro-ethane; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.3762/bjoc.12.74

upstream raw materials:

N-α-benzyloxycarbonyl-DL-tyrosine

(S)-tryptophan methyl ester hydrochloride

Z-L-Tyr-OH

N-(benzyloxycarbonyl)-O-(1,1-dimethylethyl)-L-tyrosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

✦Write with AI

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1108146-41-3 (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send