N-methyl-2-phenyl-5-methylindole

Base Information

• Chemical Name: N-methyl-2-phenyl-5-methylindole
• CAS No.: 132554-35-9
• Molecular Formula: C₁₆H₁₅N
• Molecular Weight: 221.302
• Mol file: 132554-35-9.mol

Synonyms:N-methyl-2-phenyl-5-methylindole

Chemical Property of N-methyl-2-phenyl-5-methylindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-2-phenyl-5-methylindole

There total 18 articles about N-methyl-2-phenyl-5-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N-dimethyl-4-methyl-2-(phenylethynyl)aniline → N-methyl-2-phenyl-5-methylindole (132554-35-9)

Guidance literature:

With toluene-4-sulfonic acid; silver(l) oxide; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Schlenk technique;

DOI:10.1002/ejoc.202001465

Reference yield: 88.0%

methylamine (74-89-5) + 1-bromo-2-(phenylethynyl)-4-methylbenzene (264912-27-8) → N-methyl-2-phenyl-5-methylindole (132554-35-9)

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; OTips-DalPhos; potassium tert-butylate; In tetrahydrofuran; toluene; at 90 ℃; for 12h; Sealed vial;

DOI:10.1039/c2cc33071g

Reference yield: 81.0%

1,5-dimethyl-1H-indole (27816-53-1) + diphenyliodonium tetrafluoroborate → N-methyl-2-phenyl-5-methylindole (132554-35-9)

Guidance literature:

With palladium containing [Zr₆O₄(OH)₄(terephthalate)_4.75(1,2,4,5-benzenetetracarboxylate)_1.25]; at 80 ℃; for 5h;

DOI:10.1002/cssc.202000378

upstream raw materials:

5-methyl-2-phenyl-1H-indole

3-(5-Methyl-pyridin-2-yl)-1-phenyl-propan-1-one

1,5-dimethyl-1H-indole

phenylboronic acid

Downstream raw materials:

(1,5-dimethyl-2-phenyl-indol-3-yl)-glyoxylic acid dimethylamide

1,5-dimethyl-2-phenyl-1H-indole-3-carbaldehyde

1,5-dimethyl-2-phenyl-1H-indole-3-carbonitrile

3,3-difluoro-1,5-dimethyl-2-phenylindolin-2-ol