1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Base Information

Chemical Name:1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline
CAS No.:158837-97-9
Molecular Formula:C₂₅H₂₄N₄O₃
Molecular Weight:428.491
Hs Code.:

Synonyms:1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Suppliers and Price of 1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

There total 16 articles about 1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 158837-96-8
5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

: 158837-97-9
1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Guidance literature:: 5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine; With sulfuric acid; sodium nitrite;

With sodium azide; at 0 ℃; for 0.5h;
DOI:10.1021/jo030287t

Reference yield:

: 158837-95-7
8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

: 158837-97-9
1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / sodium thiosulfate / ethanol; H₂O / 1 h / 80 °C

2.1: NaNO₂; H₂SO₄

2.2: 83 percent / NaN₃ / 0.5 h / 0 °C

With sulfuric acid; sodium thiosulfate; sodium nitrite; In ethanol; water;
DOI:10.1021/jo030287t

Reference yield:

: 904-42-7
2-Phenyl-4-(3-nitro-4-methoxy-benzyliden)-4H-(1,3)-oxazol-5-on

: 158837-97-9
1-(3-Azido-4-methoxy-benzyl)-8-benzyloxy-7-methoxy-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaOH / 90 °C

1.2: 80 percent / H₂O₂

2.1: 720 mg / Mitsunobu conditions

3.1: 78 percent / toluene / 14 h / 75 °C

4.1: n-BuLi / tetrahydrofuran; hexane / -10 - 5 °C

5.1: 88 percent / sodium thiosulfate / ethanol; H₂O / 1 h / 80 °C

6.1: NaNO₂; H₂SO₄

6.2: 83 percent / NaN₃ / 0.5 h / 0 °C

With sodium hydroxide; n-butyllithium; sulfuric acid; sodium thiosulfate; sodium nitrite; In tetrahydrofuran; ethanol; hexane; water; toluene; 4.1: aza-Wittig reaction;
DOI:10.1021/jo030287t