8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

Base Information

Chemical Name:8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline
CAS No.:158837-95-7
Molecular Formula:C₂₅H₂₄N₂O₅
Molecular Weight:432.476
Hs Code.:

Synonyms:8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

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Chemical Property of 8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

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Technology Process of 8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

There total 14 articles about 8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160857-67-0
8-benzyloxy-5-bromo-7-methoxy-1-(3-nitro-4-methoxybenzyl)-3,4-dihydroisoquinoline

: 158837-95-7
8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -10 - 5 ℃;
DOI:10.1021/jo030287t

Reference yield:

: 904-42-7
2-Phenyl-4-(3-nitro-4-methoxy-benzyliden)-4H-(1,3)-oxazol-5-on

: 158837-95-7
8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOH / 90 °C

1.2: 80 percent / H₂O₂

2.1: 720 mg / Mitsunobu conditions

3.1: 78 percent / toluene / 14 h / 75 °C

4.1: n-BuLi / tetrahydrofuran; hexane / -10 - 5 °C

With sodium hydroxide; n-butyllithium; In tetrahydrofuran; hexane; toluene; 4.1: aza-Wittig reaction;
DOI:10.1021/jo030287t

Reference yield:

: 6451-86-1
5-benzyloxy-2-bromo-4-methoxybenzaldehyde

: 158837-95-7
8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: AcONH₄; AcOH / 3 h / 80 °C

2: 72 percent / LAH / tetrahydrofuran / 8 h / 70 °C

3: 79 percent / CCl₄ / CH₂Cl₂ / 72 h / 40 °C

4: 95 percent / sodium amide / toluene / 1 h / 100 °C

5: 78 percent / toluene / 14 h / 75 °C

6: n-BuLi / tetrahydrofuran; hexane / -10 - 5 °C

With tetrachloromethane; lithium aluminium tetrahydride; n-butyllithium; ammonium acetate; sodium amide; acetic acid; In tetrahydrofuran; hexane; dichloromethane; toluene; 5: aza-Wittig reaction;
DOI:10.1021/jo030287t