5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

Base Information

Chemical Name:5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine
CAS No.:158837-96-8
Molecular Formula:C₂₅H₂₆N₂O₃
Molecular Weight:402.493
Hs Code.:

Synonyms:5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

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Chemical Property of 5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

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Technology Process of 5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

There total 14 articles about 5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 158837-95-7
8-Benzyloxy-7-methoxy-1-(4-methoxy-3-nitro-benzyl)-3,4-dihydro-isoquinoline

: 158837-96-8
5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

Guidance literature:: With sodium hydrogensulfite; In ethanol; at 80 ℃; for 1h;
DOI:10.1021/ja00100a048

Reference yield:

: 904-42-7
2-Phenyl-4-(3-nitro-4-methoxy-benzyliden)-4H-(1,3)-oxazol-5-on

: 158837-96-8
5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaOH / 90 °C

1.2: 80 percent / H₂O₂

2.1: 720 mg / Mitsunobu conditions

3.1: 78 percent / toluene / 14 h / 75 °C

4.1: n-BuLi / tetrahydrofuran; hexane / -10 - 5 °C

5.1: 88 percent / sodium thiosulfate / ethanol; H₂O / 1 h / 80 °C

With sodium hydroxide; n-butyllithium; sodium thiosulfate; In tetrahydrofuran; ethanol; hexane; water; toluene; 4.1: aza-Wittig reaction;
DOI:10.1021/jo030287t

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 158837-96-8
5-(8-Benzyloxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-2-methoxy-phenylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 78 percent / acetyl nitrate / acetonitrile / 0 - 20 °C

2.1: 100 percent / sodium acetate / 0.08 h / microwave irradiation

3.1: NaOH / 90 °C

3.2: 80 percent / H₂O₂

4.1: 720 mg / Mitsunobu conditions

5.1: 78 percent / toluene / 14 h / 75 °C

6.1: n-BuLi / tetrahydrofuran; hexane / -10 - 5 °C

7.1: 88 percent / sodium thiosulfate / ethanol; H₂O / 1 h / 80 °C

With sodium hydroxide; n-butyllithium; nitro acetate; sodium acetate; sodium thiosulfate; In tetrahydrofuran; ethanol; hexane; water; toluene; acetonitrile; 6.1: aza-Wittig reaction;
DOI:10.1021/jo030287t