Technology Process of ethyl 3-fluoro-6-phenylpicolinate
There total 3 articles about ethyl 3-fluoro-6-phenylpicolinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Hexafluorobenzene; tetra-n-butylammonium cyanide;
In
dimethyl sulfoxide;
at 25 ℃;
for 24h;
DOI:10.1021/jo5003054
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid / 5 h / Reflux
2: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / toluene / 12 h / 120 °C / Schlenk technique; Inert atmosphere
3: tetra-n-butylammonium cyanide; Hexafluorobenzene / dimethyl sulfoxide / 24 h / 25 °C
With
potassium fluoride; tetrakis(triphenylphosphine) palladium(0); Hexafluorobenzene; sulfuric acid; tetra-n-butylammonium cyanide;
In
dimethyl sulfoxide; toluene;
DOI:10.1021/jo5003054
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / toluene / 12 h / 120 °C / Schlenk technique; Inert atmosphere
2: tetra-n-butylammonium cyanide; Hexafluorobenzene / dimethyl sulfoxide / 24 h / 25 °C
With
potassium fluoride; tetrakis(triphenylphosphine) palladium(0); Hexafluorobenzene; tetra-n-butylammonium cyanide;
In
dimethyl sulfoxide; toluene;
DOI:10.1021/jo5003054
