(+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol

Base Information

• Chemical Name: (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol
• CAS No.: 163230-01-1
• Molecular Formula: C₃₀H₄₄O₄Si
• Molecular Weight: 496.762
• Mol file: 163230-01-1.mol

Synonyms:(+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol

Chemical Property of (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol

There total 1 articles about (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(-)-[2S,(2R*,6S*)]-12,12-Dimethoxy-2-[(1,1-dimethylethyl)dimethyl]silyloxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yne → (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol (163230-01-1)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; Yield given;

DOI:10.1016/0040-4039(95)00207-S

Reference yield:

sodium bis(2-methoxyethoxy)aluminum dihydride + (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol (163230-01-1) → (-)-[2S(2R*,6S*),3Z]-4-Iodo-12,12-dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-en-2-ol (185980-43-2)

Guidance literature:

With iodine; sodium thiosulfate; In tetrahydrofuran; hexane; ethyl acetate; toluene;

Reference yield:

carbon monoxide (201230-82-2) + (+)-[2S,(2R*,6S*)]-12,12-Dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-yn-2-ol (163230-01-1) → (S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-8,8-dimethoxy-octyl]-5-methyl-5H-furan-2-one

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; iodine; sodium bis(2-methoxyethoxy)aluminium dihydride; hydrazine; Yield given. Multistep reaction; 3.) THF, 45 psi;

DOI:10.1016/0040-4039(95)00207-S

Downstream raw materials:

(-)-[2S(2R*,6S*),3Z]-4-Iodo-12,12-dimethoxy-6-[(1,1-dimethylethyl)diphenyl]silyloxydodec-3-en-2-ol