(2R)-3-phenyl-2-(N-anilinyloxy)propanal

Base Information

• Chemical Name: (2R)-3-phenyl-2-(N-anilinyloxy)propanal
• CAS No.: 771476-41-6
• Molecular Formula: C₁₅H₁₅NO₂
• Molecular Weight: 241.29
• Mol file: 771476-41-6.mol

Synonyms:(2R)-3-phenyl-2-(N-anilinyloxy)propanal

Chemical Property of (2R)-3-phenyl-2-(N-anilinyloxy)propanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-phenyl-2-(N-anilinyloxy)propanal

There total 1 articles about (2R)-3-phenyl-2-(N-anilinyloxy)propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-phenyl-propionaldehyde (104-53-0) + Nitrosobenzene (586-96-9) → (2R)-3-phenyl-2-(N-anilinyloxy)propanal (771476-41-6)

Guidance literature:

With L-proline; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1002/chem.200400137

Reference yield: 64.0%

ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate (124755-24-4) + (2R)-3-phenyl-2-(N-anilinyloxy)propanal (771476-41-6) → (R)-(E)-ethyl 4-hydroxy-5-phenylpent-2-enoate (1071998-95-2) + (R)-5-benzylfuran-2(5H)-one

Guidance literature:

ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate; With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere;

(2R)-3-phenyl-2-(N-anilinyloxy)propanal; In tetrahydrofuran; at -20 ℃; for 3h; Inert atmosphere;

With copper diacetate; In tetrahydrofuran; methanol; at 20 ℃; for 12h; optical yield given as %ee; Inert atmosphere;

DOI:10.1016/j.tetasy.2012.02.004

Reference yield:

(2R)-3-phenyl-2-(N-anilinyloxy)propanal (771476-41-6) → (R)-3-phenyl-2-(N-phenylaminooxy)propan-1-ol (608130-32-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 ℃; for 0.333333h;

DOI:10.1021/ja037096s

upstream raw materials:

3-phenyl-propionaldehyde

Nitrosobenzene

Downstream raw materials:

(R)-3-phenyl-2-(N-phenylaminooxy)propan-1-ol

(R)-3-phenylpropane-1,2-diol

(R)-(E)-ethyl 4-hydroxy-5-phenylpent-2-enoate