N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

Base Information

Chemical Name:N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine
CAS No.:1185282-08-9
Molecular Formula:C₂₃H₂₅FN₄O₄
Molecular Weight:440.474
Hs Code.:

Synonyms:N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

Suppliers and Price of N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

There total 2 articles about N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.6%

: 1185287-56-2
((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

: 1185282-08-9
N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 18 - 25 ℃; for 5h; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1185287-64-2
((S)-2-amino-3,3-dimethyl butyrylamino)acetic acid benzyl ester hydrochloride

: 50264-63-6
1-(4-fluoro-benzyl)-1H-indazole-3-carboxylic acid

: 1185282-08-9
N-{[1-(4-fluorobenzyl)-1H-indazol-3-yl]carbonyl}-3-methyl-L-valylglycine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 18 - 25 °C / Inert atmosphere

1.2: 18 h / 18 - 25 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 18 - 25 °C / 760.05 Torr / Inert atmosphere

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;