((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

Base Information

Chemical Name:((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester
CAS No.:1185287-56-2
Molecular Formula:C₃₀H₃₁FN₄O₄
Molecular Weight:530.599
Hs Code.:

Synonyms:((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

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Chemical Property of ((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

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Technology Process of ((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

There total 7 articles about ((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1185287-64-2
((S)-2-amino-3,3-dimethyl butyrylamino)acetic acid benzyl ester hydrochloride

: 50264-63-6
1-(4-fluoro-benzyl)-1H-indazole-3-carboxylic acid

: 1185287-56-2
((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

Guidance literature:: 1-(4-fluoro-benzyl)-1H-indazole-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 1h; Inert atmosphere;

((S)-2-amino-3,3-dimethyl butyrylamino)acetic acid benzyl ester hydrochloride; In N,N-dimethyl-formamide; at 18 - 25 ℃; for 18h;

Reference yield:

: 43120-28-1
methyl 1H-indazole-3-carboxylate

: 1185287-56-2
((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice

1.2: 5 h / 0 - 20 °C

2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 18 - 25 °C / Inert atmosphere

3.2: 18 h / 18 - 25 °C

With potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1185287-56-2
((S)-2-{[1-(4-fluorobenzyl)-1H-indazole-3-carbonyl]-amino}-3,3-dimethylbutyryl-amino)acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 25 °C / Cooling with ice

1.2: 5 h / 0 - 20 °C

2.1: sodium hydroxide / methanol / 12 h / 18 - 25 °C

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 18 - 25 °C / Inert atmosphere

3.2: 18 h / 18 - 25 °C

With potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;