ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

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Chemical Name:ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate
CAS No.:1358778-45-6
Molecular Formula:C₁₈H₂₂N₂O₅S
Molecular Weight:378.449
Hs Code.:

Synonyms:ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

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Technology Process of ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

There total 4 articles about ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 38675-31-9
4-phenyl-1H-pyrimidin-2-one

: 1312478-48-0
(2R)-ethyl 4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1358778-45-6
ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 120h;
DOI:10.1021/jm2014875

Reference yield:

: 1312478-47-9
ethyl (±)-4-bromo-2-methyl-2-(methylsulfonyl)butanoate

: 1358778-45-6
ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.02 h / Resolution of racemate

2: potassium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm2014875

Reference yield:

: 535-13-7
2-chloro-propanoic acid, ethyl ester

: 1358778-45-6
ethyl (2R)-2-methyl-2-(methylsulfonyl)-4-(2-oxo-4-phenylpyrimidin-1(2H)-yl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 20 h / 77 °C

2.1: sodium hydride / hexane; N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0 - 20 °C

3.1: ethanol / 0.02 h / Resolution of racemate

4.1: potassium carbonate / N,N-dimethyl-formamide / 120 h / 20 °C

With sodium hydride; potassium carbonate; In ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm2014875