6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Base Information

Chemical Name:6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline
CAS No.:121963-09-5
Molecular Formula:C₁₉H₁₅F₃N₂O₄
Molecular Weight:392.334
Hs Code.:

Synonyms:6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Suppliers and Price of 6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Chemical Property:

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Technology Process of 6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

There total 1 articles about 6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 81358-81-8
4-methyl-5-hydroxy-6-methoxy-8-nitroquinoline

: 705-29-3
3-Trifluoromethylbenzyl chloride

: 121963-09-5
6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Guidance literature:: With tetra(n-butyl)ammonium hydroxide; In water; chlorobenzene; at 60 - 65 ℃; for 120h;
DOI:10.1021/jm00128a010

Reference yield: 64.0%

: 121963-09-5
6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

: 121963-10-8
8-amino-6-methoxy-4-methyl-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

Guidance literature:: With hydrogen; platinum(IV) oxide; In tetrahydrofuran; ethanol; at 45 ℃; for 0.116667h; under 2585.7 Torr;
DOI:10.1021/jm00128a010

Reference yield:

: 121963-09-5
6-methoxy-4-methyl-8-nitro-5-<<3-(trifluoromethyl)benzyl>oxy>quinoline

: 121963-27-7
2,6-Dimethoxy-4-methyl-5-(3-trifluoromethyl-benzyloxy)-quinolin-8-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 64 percent / H₂ / platinum oxide / tetrahydrofuran; ethanol / 0.12 h / 45 °C / 2585.7 Torr

2: 89 percent / xylene / Heating

3: 83 percent / m-chloroperbenzoic acid / CHCl₃ / Ambient temperature

4: 83 percent / POCl₃ / CHCl₃ / Heating

5: 89 percent / N₂H₄*H₂O / ethanol; H₂O / Heating

6: 45 percent / NaH / dimethylformamide; paraffin

With hydrogen; sodium hydride; hydrazine hydrate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; platinum(IV) oxide; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; paraffin; xylene;
DOI:10.1021/jm00128a010