Technology Process of 5-cyclohexyl-N,N-dipropylisophthalamic acid methyl ester
There total 4 articles about 5-cyclohexyl-N,N-dipropylisophthalamic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cyclohexyl-3,5-dicarboxylic acid monomethyl ester;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
for 1h;
Inert atmosphere;
di-n-propylamine;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/ml4004952
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / toluene / 24 h / 90 °C / Inert atmosphere
2.1: sodium hydroxide / water; methanol / 20 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
methanol; dichloromethane; water; toluene;
DOI:10.1021/ml4004952
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / toluene / 24 h / 90 °C / Inert atmosphere
2.1: sodium hydroxide / water; methanol / 20 °C
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide;
In
methanol; dichloromethane; water; toluene;
DOI:10.1021/ml4004952
