[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

Base Information

Chemical Name:[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine
CAS No.:886854-86-0
Molecular Formula:C₂₄H₂₆N₆O
Molecular Weight:414.51
Hs Code.:

Synonyms:[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

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Chemical Property of [6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

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Technology Process of [6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

There total 7 articles about [6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886854-85-9
{4-[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-ylamino]-phenyl}-morpholin-4-yl-methanone

: 886854-86-0
[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

Guidance literature:: {4-[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-ylamino]-phenyl}-morpholin-4-yl-methanone; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Heating / reflux;

With sodium hydroxide; In water; at 0 ℃; for 0.25h;

Reference yield:

: 886854-83-7
4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid

: 886854-86-0
[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.33 h / 20 °C

1.2: 16 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 95 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Heating / reflux

3.2: 0.25 h / 0 °C

With lithium aluminium tetrahydride; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ISOPROPYLAMIDE;

Reference yield:

: 886854-81-5
4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-benzoic acid ethyl ester

: 886854-86-0
[6-(3-amino-2-methyl-phenyl)-imidazo[1,2-a]pyrazin-8-yl]-(4-morpholin-4-ylmethyl-phenyl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / ethanol / 2 h / Heating / reflux

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 0.33 h / 20 °C

2.2: 16 h / 20 °C

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 16 h / 95 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C / Heating / reflux

4.2: 0.25 h / 0 °C

With sodium hydroxide; lithium aluminium tetrahydride; water; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ISOPROPYLAMIDE;