(R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

Base Information

Chemical Name:(R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester
CAS No.:1001565-88-3
Molecular Formula:C₂₃H₂₆N₂O₆S
Molecular Weight:458.535
Hs Code.:

Synonyms:(R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

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Technology Process of (R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

There total 1 articles about (R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 98-09-9
benzenesulfonyl chloride

: 151872-21-8
(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionic acid methyl ester

: 1001565-88-3
(R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

Guidance literature:: With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; at 25 ℃; for 3h;
DOI:10.1021/ol702732j

Reference yield: 84.0%

: 1001565-88-3
(R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

: 1001565-97-4
(2R,3aS,8aS)-8-benzenesulfonyl-3a-bromo-2,3,3a,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: With magnesium bromide; In water; acetonitrile; at 20 ℃; for 2h; Electrolysis;
DOI:10.1039/c9cc09276e

Reference yield: 78.7%

: 1001565-88-3
(R)-3-(1-benzenesulfonyl-1H-indol-3-yl)-2-tert-butoxycarbonylamino-propionic acid methyl ester

: 1001565-97-4
(2R,3aS,8aS)-8-benzenesulfonyl-3a-bromo-2,3,3a,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: C₂₃H₂₅BrN₂O₆S

Guidance literature:: With N-Bromosuccinimide; pyridinium p-toluenesulfonate; In dichloromethane; at 23 ℃; for 1.5h; Overall yield = 99.6 %; Overall yield = 11.6 g; Inert atmosphere;
DOI:10.1021/jacs.6b04072