R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

Base Information

Chemical Name:R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride
CAS No.:457634-24-1
Molecular Formula:C₁₇H₂₁NO₂*ClH
Molecular Weight:307.82
Hs Code.:

Synonyms:R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

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Chemical Property of R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

Chemical Property:

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Technology Process of R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

There total 7 articles about R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (-)-N-methyl-3-phenyl-3-(o-tolyloxy-4-hydroxy)propylamine oxalate

: 457634-24-1
R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

Guidance literature:: (-)-N-methyl-3-phenyl-3-(o-tolyloxy-4-hydroxy)propylamine oxalate; With ammonia; In water; pH=10;

With hydrogenchloride; In water; ethyl acetate; pH=1;

Reference yield:

: 36296-97-6
(S)-3-(dimethylamino)-1-phenylpropan-1-ol

: 457634-24-1
R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4.5 h / 0 - 35 °C / Inert atmosphere

1.2: 10.5 h / Inert atmosphere

1.3: 12.5 h / 25 - 35 °C

2.1: 3-chloro-benzenecarboperoxoic acid; acetic acid / dichloromethane / 12 h / 25 - 35 °C

3.1: N-ethyl-N,N-diisopropylamine / toluene / 50 - 65 °C

3.2: 3 h / 60 - 85 °C

4.1: sodium hydroxide / dimethyl sulfoxide / 16 h / 50 - 55 °C

4.2: pH 2.2

5.1: ammonia / water / pH 10

5.2: pH 1

With oxalyl dichloride; ammonia; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 873436-53-4
(S)-3-(dimethylamino)-1-phenylpropan-1-ol oxalate

: 457634-24-1
R-(-)-N-methyl-3-(2-methyl-4-hydroxyphenyloxy)-3-phenyl-1-aminopropane hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / toluene; water / pH 11 - 12

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4.5 h / 0 - 35 °C / Inert atmosphere

2.2: 10.5 h / Inert atmosphere

2.3: 12.5 h / 25 - 35 °C

3.1: 3-chloro-benzenecarboperoxoic acid; acetic acid / dichloromethane / 12 h / 25 - 35 °C

4.1: N-ethyl-N,N-diisopropylamine / toluene / 50 - 65 °C

4.2: 3 h / 60 - 85 °C

5.1: sodium hydroxide / dimethyl sulfoxide / 16 h / 50 - 55 °C

5.2: pH 2.2

6.1: ammonia / water / pH 10

6.2: pH 1

With oxalyl dichloride; ammonia; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In dichloromethane; water; dimethyl sulfoxide; toluene;