(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

Base Information

Chemical Name:(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate
CAS No.:1270016-47-1
Molecular Formula:C₂H₂O₄*C₂₀H₂₅NO₂
Molecular Weight:401.459
Hs Code.:

Synonyms:(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

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Chemical Property of (R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

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Technology Process of (R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

There total 3 articles about (R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144-62-7,97993-78-7
oxalic acid

: 36296-97-6
(S)-3-(dimethylamino)-1-phenylpropan-1-ol

: sodium 4-acetyl-2-methylphenolate

: 1270016-47-1
(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

Guidance literature:: (S)-3-(dimethylamino)-1-phenylpropan-1-ol; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 35 ℃; for 4.5h; Inert atmosphere;

sodium 4-acetyl-2-methylphenolate; In dichloromethane; for 10.5h; Inert atmosphere;

oxalic acid; In ethyl acetate; acetone; at 25 - 35 ℃; for 12.5h;

Reference yield:

: 100306-34-1,125712-82-5
3-chloro-1-phenylpropanol

: 1270016-47-1
(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium iodide / ethanol / 7 h / 55 - 60 °C

1.2: pH 11 - 12

1.3: 2.5 h / 20 - 25 °C

2.1: sodium hydroxide / toluene; water / pH 11 - 12

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4.5 h / 0 - 35 °C / Inert atmosphere

3.2: 10.5 h / Inert atmosphere

3.3: 12.5 h / 25 - 35 °C

With oxalyl dichloride; N,N-dimethyl-formamide; potassium iodide; sodium hydroxide; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 873436-53-4
(S)-3-(dimethylamino)-1-phenylpropan-1-ol oxalate

: 1270016-47-1
(R)-N,N-dimetyl-3-(2-methyl-(4-acetylphenyl)oxy)-3-phenyl-1-aminopropane oxalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / toluene; water / pH 11 - 12

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 4.5 h / 0 - 35 °C / Inert atmosphere

2.2: 10.5 h / Inert atmosphere

2.3: 12.5 h / 25 - 35 °C

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; water; toluene;