Technology Process of (S)-3-(dimethylamino)-1-phenylpropan-1-ol
There total 10 articles about (S)-3-(dimethylamino)-1-phenylpropan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(dimethylamino)propiophenone hydrochloride;
With
(2R,4R)-4-(dicyclohexylphosphino)-2-(diphenylphosphino-methyl)-N-methyl-aminocarbonylpyrrolidine; hydrogen; sodium hydrogencarbonate;
chloro(1,5-cyclooctadiene)rhodium(I) dimer;
In
methanol; water;
at 30 ℃;
for 10h;
under 75007.5 Torr;
With
hydrogenchloride; water;
In
dichloromethane; toluene;
for 0.166667h;
pH=1.5;
With
sodium hydroxide; water;
pH=9.0;
- Guidance literature:
-
With
formic acid; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; triethylamine;
In
ethyl acetate;
at 20 ℃;
for 168h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium iodide / diethyl ether / 48 h / Reflux
2: [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; formic acid; triethylamine / ethyl acetate / 168 h / 20 °C / Inert atmosphere
With
formic acid; [N-[(1R,2R)-2-(amino-κN)-1,2-diphenylethyl]-4-methylbenzenesulfonamidato-κN]chloro[(1,2, 3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene]-ruthenium; triethylamine; sodium iodide;
In
diethyl ether; ethyl acetate;