(R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

Base Information

Chemical Name:(R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide
CAS No.:1188931-84-1
Molecular Formula:C₂₇H₄₃NO₄
Molecular Weight:445.643
Hs Code.:

Synonyms:(R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

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Chemical Property of (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

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Technology Process of (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

There total 6 articles about (R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1188931-83-0
(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

: 593-51-1
methylamine hydrochloride

: 1188931-84-1
(R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

Guidance literature:: With triethylamine; at 0 - 20 ℃;

Reference yield:

: C₃₉H₇₁NO₄Si₂

: 1188931-84-1
(R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

Guidance literature:: With hydrogen fluoride; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2010.03.078

Reference yield:

: 957214-13-0
(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal

: 1188931-84-1
(R)-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-N-methyl-2-oxooctanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: hydrogen fluoride / dichloromethane; acetonitrile / 2 h / 20 °C

3.1: triethylamine / 0 - 20 °C

With hydrogen fluoride; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;