(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

Base Information

Chemical Name:(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate
CAS No.:1188931-83-0
Molecular Formula:C₂₇H₄₂O₅
Molecular Weight:446.627
Hs Code.:

Synonyms:(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

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Chemical Property of (R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

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Technology Process of (R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

There total 5 articles about (R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1188932-03-7
(R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

: 1188931-83-0
(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

Guidance literature:: With hydrogen fluoride; In dichloromethane; acetonitrile; at 20 ℃; for 2h;

Reference yield:

: (R,Z)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-bis-(tert-butyldimethylsilyloxy)cyclohexylidene)ethylidene)-7a-methyl-octahydro-1H-inden-1-yl)-2-(tert-butyldimethylsilyloxy)oct-2-enoate

: 1188931-83-0
(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

Guidance literature:: With hydrogen fluoride; In dichloromethane; acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2010.03.078

Reference yield:

: 957214-13-0
(5S)-5-((1R,3R,7E,17β)-1,3-bis[tert-butyl(dimethyl)silyloxy]-9,10-secoestra-5,7-dien-17-yl)hexanal

: 1188931-83-0
(R)-methyl-7-((1R,3aS,7aR,E)-4-(2-((3R,5R)-3,5-dihydroxycyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)-2-oxooctanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: hydrogen fluoride / dichloromethane; acetonitrile / 2 h / 20 °C

With hydrogen fluoride; sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;