(S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N₅-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate.

Base Information

• Chemical Name: (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N₅-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate.
• CAS No.: 1416797-57-3
• Molecular Formula: C₂₁H₁₆F₄N₄O₂
• Molecular Weight: 432.377

Synonyms:(S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N₅-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate.

Chemical Property of (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N₅-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate.

Chemical Property:

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Technology Process of (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N₅-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate.

There total 3 articles about (S)-N₂-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N₅-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-6-(((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)carbamoyl)nicotinic acid (1416797-65-3) + methylamine (74-89-5) → (S)-N2-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N5-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate. (1416797-57-3)

Guidance literature:

With HATU; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 23 ℃; for 1h;

Reference yield:

pyridine-2,5-dicarboxylic acid 5-methyl ester (17874-79-2) → (S)-N2-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N5-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate. (1416797-57-3)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 23 °C

With HATU; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

→ (S)-N2-((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)-N5-methylpyridine-2,5-dicarboxamide 2,2,2-trifluoroacetate. (1416797-57-3)

Guidance literature:

upstream raw materials:

(S)-6-(((3-fluoropyridin-2-yl)(4-(trifluoromethyl)phenyl)-methyl)carbamoyl)nicotinic acid

methylamine

pyridine-2,5-dicarboxylic acid 5-methyl ester

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