Technology Process of 4-fluoro-2,3-dimethoxybenzaldehyde
There total 1 articles about 4-fluoro-2,3-dimethoxybenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
formaldehyd; 3-fluorocatechol;
With
triethylamine; magnesium chloride;
In
acetonitrile;
at 80 ℃;
for 8h;
With
hydrogenchloride;
In
water;
methyl iodide;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
- Guidance literature:
-
4-fluoro-2,3-dimethoxybenzaldehyde;
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
With
water;
In
methanol; dichloromethane;
at -78 - 20 ℃;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane / -78 - 20 °C
1.2: -78 - 20 °C
2.1: sodium t-butanolate / dimethyl sulfoxide / 0.25 h / 20 °C
2.2: 18 h / 20 °C
2.3: pH 3 / Cooling with ice
3.1: pyridine / dichloromethane / 5 h / 0 - 20 °C
4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 24 h / Inert atmosphere; Reflux
With
pyridine; potassium acetate; boron tribromide; sodium t-butanolate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; dichloromethane; dimethyl sulfoxide;
