2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

Base Information

Chemical Name:2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester
CAS No.:77407-05-7
Molecular Formula:C₁₈H₃₀O₆
Molecular Weight:342.433
Hs Code.:

Synonyms:2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

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Chemical Property of 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

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Technology Process of 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

There total 7 articles about 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 22348-95-4
methyl 3-oxooctanoate

: 77406-92-9
2-methylene-3-(methoxymethyloxy) cyclohexanone

: 77407-05-7
2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

Guidance literature:: With sodium hydride; In benzene; Ambient temperature;
DOI:10.1016/0040-4039(81)80164-5

Reference yield:

: 77406-94-1
2-Diethoxymethyl-6-iodo-hex-1-en-3-ol

: 77407-05-7
2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 2.) copper sulfate / 1.) diethylaniline, room temperature, 12 h, 2.) methanol-water, room temperature, 1 h

2: ZnI₂ / 1 h / warmed from 0 deg C to room temperature

3: 3N HCl / tetrahydrofuran / 0.25 h / 0 °C

4: p-TsOH / benzene

5: 79 percent / sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 40 °C

6: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min

7: 72 percent / NaH / benzene / Ambient temperature

With hydrogenchloride; sodium hydroxide; copper(I) sulfate; sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid; zinc(II) iodide; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4039(81)80164-5

Reference yield:

: 77406-95-2
6-Iodo-3-methoxymethoxy-2-methylene-hexanal

: 77407-05-7
2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: ZnI₂ / 1 h / warmed from 0 deg C to room temperature

2: 3N HCl / tetrahydrofuran / 0.25 h / 0 °C

3: p-TsOH / benzene

4: 79 percent / sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 40 °C

5: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min

6: 72 percent / NaH / benzene / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid; zinc(II) iodide; In tetrahydrofuran; benzene;
DOI:10.1016/0040-4039(81)80164-5