Technology Process of 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester
There total 7 articles about 2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 2.) copper sulfate / 1.) diethylaniline, room temperature, 12 h, 2.) methanol-water, room temperature, 1 h
2: ZnI2 / 1 h / warmed from 0 deg C to room temperature
3: 3N HCl / tetrahydrofuran / 0.25 h / 0 °C
4: p-TsOH / benzene
5: 79 percent / sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 40 °C
6: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min
7: 72 percent / NaH / benzene / Ambient temperature
With
hydrogenchloride; sodium hydroxide; copper(I) sulfate; sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid;
zinc(II) iodide;
In
tetrahydrofuran; benzene;
DOI:10.1016/0040-4039(81)80164-5
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ZnI2 / 1 h / warmed from 0 deg C to room temperature
2: 3N HCl / tetrahydrofuran / 0.25 h / 0 °C
3: p-TsOH / benzene
4: 79 percent / sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / 40 °C
5: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min
6: 72 percent / NaH / benzene / Ambient temperature
With
hydrogenchloride; sodium hydroxide; sodium hexamethyldisilazane; sodium hydride; toluene-4-sulfonic acid;
zinc(II) iodide;
In
tetrahydrofuran; benzene;
DOI:10.1016/0040-4039(81)80164-5
