3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester

Base Information

• Chemical Name: 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester
• CAS No.: 77407-09-1
• Molecular Formula: C₁₆H₂₄O₄
• Molecular Weight: 280.364
• Mol file: 77407-09-1.mol

Synonyms:3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester

Chemical Property of 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester

There total 3 articles about 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester (77407-05-7) → 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester (77407-09-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; diethyl ether; for 3h; Ambient temperature;

DOI:10.1016/0040-4039(81)80164-5

Reference yield:

2-methylene-3-(methoxymethyloxy) cyclohexanone (77406-92-9) → 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester (77407-09-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / NaH / benzene / Ambient temperature

2: 78 percent / aq. NaOH (10percent) / diethyl ether; tetrahydrofuran / 3 h / Ambient temperature

With sodium hydroxide; sodium hydride; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1016/0040-4039(81)80164-5

Reference yield:

1-(1-Ethoxy-ethoxy)-3-methoxymethoxy-2-methylene-cyclohexanecarbonitrile (77406-99-6) → 3-Oxo-2-(6-oxo-cyclohex-1-enylmethyl)-octanoic acid methyl ester (77407-09-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 3N HCl, 2.) 0.5percent NaOH / 1.) THF, 0deg C, 1 h, 2.) ether, 0 deg C, 1 min

2: 72 percent / NaH / benzene / Ambient temperature

3: 78 percent / aq. NaOH (10percent) / diethyl ether; tetrahydrofuran / 3 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium hydride; In tetrahydrofuran; diethyl ether; benzene;

DOI:10.1016/0040-4039(81)80164-5

upstream raw materials:

2-(2-Methoxymethoxy-6-oxo-cyclohexylmethyl)-3-oxo-octanoic acid methyl ester

2-methylene-3-(methoxymethyloxy) cyclohexanone

1-(1-Ethoxy-ethoxy)-3-methoxymethoxy-2-methylene-cyclohexanecarbonitrile