N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

Base Information

Chemical Name:N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine
CAS No.:1440672-10-5
Molecular Formula:C₂₀H₁₉BrFNO₂
Molecular Weight:404.279
Hs Code.:

Synonyms:N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

Suppliers and Price of N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

There total 2 articles about N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 351002-93-2
4-ethynyl-1-fluoro-2-methylbenzene

: 1440672-10-5
N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

2: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 24 h / Inert atmosphere; Reflux

With potassium phosphate; N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; silver nitrate; In acetone; toluene;
DOI:10.1021/ol4013298

Reference yield:

: 1211318-55-6
4-(2-bromoethynyl)-1-fluoro-2-methylbenzene

: 78839-75-5
2-bromo-N-(tert-butoxycarbonyl)aniline

: 1440672-10-5
N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

Guidance literature:: With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/ol4013298

Reference yield: 42.0%

: 1440672-10-5
N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine

: 1440673-12-0
N-tert-butoxycarbonyl-3-(3-methyl-4-fluorophenyl)indole

Guidance literature:: N-(2-bromophenyl)-N-tert-butoxycarbonyl-(4-fluoro-3-methylphenyl)ethynylamine; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; Inert atmosphere;

With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; diethyl ether; pentane; at -78 - 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol4013298