(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Base Information

Chemical Name:(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol
CAS No.:852661-52-0
Molecular Formula:C₂₉H₃₇FN₂O
Molecular Weight:448.624
Hs Code.:

Synonyms:(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Chemical Property:

Purity/Quality:

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Technology Process of (2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

There total 8 articles about (2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852661-51-9
1-(para-fluorophenyl)-3-(ethylamino)propane

: 852661-53-1
(1R)-N,N-dibenzyl-1-[(2S)-oxiran-2-yl]ethanamine

: 852661-52-0
(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: In ethanol; for 20h; Heating;
DOI:10.1016/j.bmcl.2007.11.087

Reference yield:

: 7116-38-3
ethyl 3-(4-fluorophenyl)propanoate

: 852661-52-0
(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide; water / methanol / Heating / reflux

1.2: pH 1

2.1: thionyl chloride / dichloromethane / 24 h / 25 °C

3.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

5.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 25 °C / Heating / reflux

7.1: ethanol / 25 °C / Heating / reflux

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;

Reference yield:

: 136265-10-6,352-03-4,24393-50-8
ethyl 4-fluorocinnamate

: 852661-52-0
(2S,3R)-3-(dibenzylamino)-1-{ethyl[3-(4-fluorophenyl)propyl]amino}butan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 2585.81 Torr

2.1: sodium hydroxide; water / methanol / Heating / reflux

2.2: pH 1

3.1: thionyl chloride / dichloromethane / 24 h / 25 °C

4.1: ammonia / tetrahydrofuran; water / 2 h / 0 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 0 - 20 °C

6.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.17 h / 25 °C / Heating / reflux

8.1: ethanol / 25 °C / Heating / reflux

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; ammonia; water; hydrogen; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;