rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

Base Information

Chemical Name:rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide
CAS No.:1558680-89-9
Molecular Formula:C₂₂H₂₂F₆N₂O₄S
Molecular Weight:524.484
Hs Code.:

Synonyms:rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

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Technology Process of rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

There total 8 articles about rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1236303-73-3
rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

: 124-63-0
methanesulfonyl chloride

: 1558680-89-9
rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ml500005m

Reference yield:

: 622-42-4
1-nitro-1-phenylmethane

: 1558680-89-9
rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 8 steps

1: Amberlyst A-21 / 1,4-dioxane / 20 °C

2: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

3: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

8: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Mannich Aminomethylation;
DOI:10.1021/ml500005m

Reference yield:

: 22049-87-2
rac-4-nitro-4-phenyl-butyric acid methyl ester

: 1558680-89-9
rac-N-(1-methanesulfonyl-3-phenyl-piperidin-3-yl)-2-methoxy-4,6-bis-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

2: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

4: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

6: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1: |Mannich Aminomethylation;
DOI:10.1021/ml500005m