rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Base Information

Chemical Name:rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide
CAS No.:1236303-73-3
Molecular Formula:C₂₁H₂₀F₆N₂O₂
Molecular Weight:446.392
Hs Code.:

Synonyms:rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Suppliers and Price of rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

There total 8 articles about rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1236303-75-5
rac-3-(2-methoxy-4,6-bis-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid benzyl ester

: 1236303-73-3
rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1.5h;

Reference yield: 86.0%

: 1558682-36-2
rac-3-(2-methoxy-4-methyl-6-trifluoromethyl-benzoylamino)-3-phenyl-piperidine-1-carboxylic acid tert-butyl ester

: 1236303-73-3
rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h;
DOI:10.1021/ml500005m

Reference yield:

: 622-42-4
1-nitro-1-phenylmethane

: 1236303-73-3
rac-2-methoxy-N-(3-phenyl-piperidin-3-yl)-4,6-bis-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: Amberlyst A-21 / 1,4-dioxane / 20 °C

2: ammonium acetate / water; ethanol / 26 h / Inert atmosphere; Reflux

3: hydrogen / tetrahydrofuran; water / 7 h / 0 °C / 760.05 Torr

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Reflux

5: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

7: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; ammonium acetate; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 2: |Mannich Aminomethylation;
DOI:10.1021/ml500005m