2-AMINO-2-METHYL-PROPIONITRILE

Base Information

• Chemical Name: 2-AMINO-2-METHYL-PROPIONITRILE
• CAS No.: 19355-69-2
• Molecular Formula: C4H8N2
• Molecular Weight: 84.1209
• Hs Code.: 2926909090
• European Community (EC) Number: 242-989-3
• UNII: KA4O623NBV
• DSSTox Substance ID: DTXSID0027804
• Nikkaji Number: J27.748G
• Wikidata: Q27282150
• ChEMBL ID: CHEMBL3188413
• Mol file: 19355-69-2.mol

Synonyms:Propionitrile,2-amino-2-methyl- (6CI,7CI,8CI);1-Cyano-1-methylethylamine;2-Amino-2-cyanopropane;2-Amino-2-methylpropionitrile;2-Aminoisobutyronitrile;2-Aminopropane-2-carbonitrile;2-Cyanoisopropylamine;a-Amino-a-methylpropionitrile;a-Aminoisobutyronitrile;

Chemical Property of 2-AMINO-2-METHYL-PROPIONITRILE

Chemical Property:

• Vapor Pressure: 0.662mmHg at 25°C
• Refractive Index: 1.434
• Boiling Point: 150.4 °C at 760 mmHg
• PKA: 5.06±0.25(Predicted)
• Flash Point: 44.7 °C
• PSA: 49.81000
• Density: 0.917 g/cm³
• LogP: 0.94758
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 84.068748264
• Heavy Atom Count: 6
• Complexity: 85

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-2-methylpropanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-43-41-37/38-22
• Safety Statements: 26-36/37/39-39-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C#N)N

Technology Process of 2-AMINO-2-METHYL-PROPIONITRILE

There total 17 articles about 2-AMINO-2-METHYL-PROPIONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-hydroxy-2-methylpropanenitrile (75-86-5) → 2-amino-2-cyanopropane (19355-69-2)

Guidance literature:

With ammonia; at 10 ℃; under 258.581 - 1551.49 Torr;

Reference yield: 95.0%

sodium cyanide (773837-37-9) + acetone (67-64-1) → 2-amino-2-cyanopropane (19355-69-2)

Guidance literature:

With ammonium hydroxide; ammonium chloride; In water; at 0 - 20 ℃;

Reference yield: 84.4%

sodium cyanide (143-33-9,25596-52-5) + acetone (67-64-1) → 2-amino-2-cyanopropane (19355-69-2)

Guidance literature:

With ammonium hydroxide; ammonium chloride; In water; 5 deg C, 15 min; room temperature, 60 h;

DOI:10.1016/S0040-4020(97)10244-7

upstream raw materials:

potassium cyanide

2-hydroxy-2-methylpropanenitrile

hydrogen cyanide

acetone

Downstream raw materials:

N-(1-cyano-1-methylethyl)-2-methylpropanamide

α-isobutyrylamino-isobutyric acid

N-(1-cyano-1-methyl-ethyl)-toluene-4-sulfonamide

5,5-dimethylimidazolidine-2,4-dithione

Refernces

• 1、 Kotlyar, Volodymyr M.,Kolomoitsev, Oleksii O.,Nikolaievskyi, Dmytro V.,Pedan, Polina I.,Chumak, Andrii Yu,Orlov, Valery D.,Shishkina, Svitlana V.,Doroshenko, Andrey O.. "Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs". . p. 741 - 746. Retrieved 2019/01/10.
• 2、 Islam, Saidul,Bu?ar, Dejan-Kre?imir,Powner, Matthew W.. "Prebiotic selection and assembly of proteinogenic amino acids and natural nucleotides from complex mixtures". . p. 584 - 589. Retrieved 2017/05/31.